Ole Gunnar Solskjaer’s side are set to travel further than any of their top-six rivals, including a trip to Australia to face Leeds United.
Premier League champions Manchester City visit China, Singapore and Japan while Liverpool head to the USA.
Both Chelsea and Arsenal face Barcelona as part of their preparations.
The Gunners are the first English side to play Barca in the annual Joan Gamper Trophy at the Nou Camp since Manchester City beat the La Liga champions a decade ago.
Several Premier League teams will meet this summer with City, Newcastle, West Ham and Wolves all competing in the Premier League Asia Trophy in China.
Manchester United and Tottenham play one another in Shanghai in the International Champions Cup, which also pits Spurs against Juventus in Singapore before they host Inter Milan at the Tottenham Hotspur Stadium.
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